Endocrine Abstracts

Background: Hoffmann syndrome is a rare form of hypothyroid myopathy in adults characterized by presence of muscle weakness, stiffness and pseudo-hypertrophy. Here, we report a case of Hoffman syndrome aggravated by statin therapy.Case report: We describe the case of a 60 year old woman with primary hypothyroidism who presented with fatigue, cold intolerance, constipation, exertional breathlessness, progressive proximal muscle weakness and swelling of th...

Introduction: Metabolic steatopathy is frequently associated with type 2 diabetes, which may progress to advanced fibrosis. The objectives of this study were to evaluate the prevalence and predictors of the severity of hepatic impairment in this population.Methods: A cross-sectional study involving 281 type 2 diabetic patients followed in the endocrinology department in collaboration with the Hepato-Gastroenterology department of Ibn Rochd University Hos...

Introduction: Metabolic liver steatosis is frequently associated with type 2 diabetes with an increased risk of progression to advanced fibrosis. Objective of this study was to estimate the prevalence of hepatic steatosis in patients with type 2 diabetes.Methods: A cross-sectional study including 281 type 2 diabetic patients followed at the Department of Endocrinology in collaboration with the Hepato-Gastroenterology Department of Ibn Rochd University Ho...

Introduction: Metabolic hepatic steatosis is a common condition in patients with type 2 diabetes, increasing the risk of cardiovascular morbidity and mortality in the absence of early and adequate management. The objective of this study was to evaluate cardiovascular risk in this population by comparing it with diabetic patients without fatty liver disease.Methods: We conclucted a cross-sectional study including 281 type 2 diabetics followed in Endocrino...

Introduction: Acromegaly is a chronic disorder usually caused by growth hormone (GH)-secreting pituitary adenomas. Transsphenoidal surgery remains a treatment of choice for restoring GH to normal levels. The aim of this study was to illustrate the relationship between some factors and transsphenoidal surgery outcomes.Patients and methods: We retrospectively analysed the outcome of 31 patients with acromegaly after initial endoscopic transsphenoidal surge...

Introduction: Congenital adrenal hyperplasia (CAH) due to an enzymatic defect in 11-beta-hydroxylase (11β-OHD) is the second most common cause of CAH representing 5-8% of cases. It is characterized by androgen excess, hypertension and hypokalemia. Here we describe the case of a patient having a CYP11B1 mutation and being followed-up during 33 years.Observation: A 36-year-old Tunisian male was diagnosed with 11β-OHD at the age of three years rev...